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Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton.
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Human Polyclonal GRAF Primary Antibody for ELISA, WB - ABIN250050
Borkhardt, Bojesen, Haas, Fuchs, Bartelheimer, Loncarevic, Bohle, Harbott, Repp, Jaeger, Viehmann, Henn, Korth, Scharr, Lampert: The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q. in Proceedings of the National Academy of Sciences of the United States of America 2000
Human Polyclonal GRAF Primary Antibody for IHC, IHC (p) - ABIN4315973
Bozóky, Savchenko, Csermely, Korcsmáros, Dúl, Pontén, Székely, Klein: Novel signatures of cancer-associated fibroblasts. in International journal of cancer 2013
GRAF1 plays a role in the maintenance of normal epithelial phenotype and its depletion leads to an epithelial-mesenchymal transition-like process that might be involved in neoplastic transformation.
We conclude that a transient interaction between Cdc42 (show CDC42 Antibodies) and GRAF1 drives endocytic turnover and controls the transition essential for endosomal maturation of plasma membrane internalised by this mechanism.
GRAF expression is a favorable prognostic marker in patients with acute myeloid leukemia (show BCL11A Antibodies).
ADAR1 (show ADAR Antibodies) regulates the expression of ARHGAP26 through A-to-I RNA editing by disrupting the binding of miR (show MLXIP Antibodies)-30b-3p and miR (show MLXIP Antibodies)-573 within the 3' UTR (show UTS2R Antibodies) of ARHGAP26.
proposed that GRAF1 remodels membrane microdomains at adhesion sites into endocytic carriers, facilitating membrane turnover during cell morphological changes
Findings suggest that the hypermethylation of GRAF promoter might be one of early events in the development of AML (show RUNX1 Antibodies).
a GTPase-activating protein (show RASA1 Antibodies) that regulates muscle maturation and to highlight the functional importance of BAR domains in myotube formation
Decreased level of GRAF transcript is associated with acute myeloid leukemia (show BCL11A Antibodies), myelodysplastic syndrome and chronic myeloid leukemia (show BCL11A Antibodies).
The GRAF gene was down-regulated in AML (show RUNX1 Antibodies), which might play a role in the leukemogenesis.
The analysis of the expression pattern of the GRAF1/OPHN-1 (show OPHN1 Antibodies)-L gene in human tissues and organs revealed the predominant brain expression of a novel splicing isoform.
GRAF1 and 2 facilitate myoblast fusion, at least in part, by promoting vesicle-mediated translocation of fusogenic ferlin proteins to the plasma membrane.
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene.
Rho GTPase activating protein 26
, rho GTPase-activating protein 26-like
, GTPase regulator associated with focal adhesion kinase pp125(FAK)
, oligophrenin-1-like protein
, rho GTPase-activating protein 26
, rho-type GTPase-activating protein 26
, GTPase regulator associated with focal adhesion kinase
, rhoGap protein