Waglerin 1

Catalog No. ABIN1540138

Product Details

Target: Waglerin 1

Application: Blocking Reagent (BR)

Purpose: Waglerin is a nAChR blocker

Sequence: Gly-Gly-Lys-Pro-Asp-Leu-Arg-Pro-Cys9-His-Pro-Pro-Cys13-His-Tyr-Ile-Pro-Arg-Pro-Lys-Pro-Arg-OH(Disulfide bonds between Cys9-Cys13)

Application Details

Restrictions: For Research Use only

Handling

Target Details

Target: Waglerin 1

Background: Waglerin 1 (Wtx-1) is a peptide originally isolated from the venom of the Wagler's pit viper (Trimeresurus wagleri). This 22 amino-acid peptide is a competitive antagonist of muscle nicotinic acetylcholine receptors. Waglerin 1 binds selectively to epsilon subunit of nAChR. Some studies have demonstrated that Waglerin 1 has an effect on ionotropic GABA receptors. It may potentiate or depress I(GABA) depending on the neurons. Some derivatives of Waglerin 1 are currently used in cosmetics to reduce wrinkles.

Molecular Weight: 2520 Da