α-conotoxin PeIA

Catalog No. ABIN2566209

Product Details

Application: Blocking Reagent (BR)

Sequence: AA sequence: Gly-Cys2-Cys3-Ser-His-Pro-Ala-Cys8-Ser-Val -Asn-His-Pro-Glu-Leu-Cys16-NH2 Disulfide bonds: Cys2-Cys8, Cys3-Cys16

Characteristics: α-conotoxin PeIA discriminates between α9α10 and α7 nAChRs

Application Details

Restrictions: For Research Use only

Handling

Storage: -20 °C

Target Details

Background: α-conotoxin PeIA has been isolated from the venom of Conus pergrandis. α-conotoxin PeIA discriminates between α9α10 and α7 nicotinic acetylcholine receptors (AChRs) with IC50 values of 7-50 nM (depending of the authors) and 1.8 μM, respectively ). α-conotoxin PeIA is also known to block α3β2 nicotinic AChRs (with an IC50 of 97 nM) and block voltage-gated N-type Ca2+ channels in rat DRG neurons with an IC50 of 1.1 nM. No significant inhibition of ACh-evoked currents for nicotinic α4β2 and muscle αβγδ AChRs by 1 μM α-conotoxin PeIA. The action of α-conotoxin PeIA is fully reversible after washout of the peptide in the extracellular medium.

Molecular Weight: 1651.9 kDa