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|Antigen||DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) Antibodies|
|Epitope||AA 871-925 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This DDX58 antibody is un-conjugated Alternatives|
Western Blotting (WB)
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Product Details anti-DDX58 AntibodyTarget Details DDX58 Application Details Handling Images
|Purpose||Rabbit IgG polyclonal antibody for Probable ATP-dependent RNA helicase DDX58(DDX58) detection. Tested with WB in Human,Mouse,Rat.|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for Probable ATP-dependent RNA helicase DDX58(DDX58) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: DExD/H-box helicase 58
Protein Name: Probable ATP-dependent RNA helicase DDX58
|Purification||Immunogen affinity purified.|
|Immunogen||E. coli-derived human DDX58 recombinant protein (Position: H871-K925). Human DDX58 shares 83.3% amino acid (aa) sequence identity with mouse DDX58.|
|Plasmids, Primers & others|
Target Details DDX58Product Details anti-DDX58 Antibody Application Details Handling Images back to top
|Alternative Name||DDX58 (DDX58 Antibody Abstract)|
RIG-I (retinoic acid-inducible gene I) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded (in humans) by the DDX58 gene. RIG-I is part of the RIG-I-like receptor family, which also includes MDA5 and LGP2, and functions as a pattern recognition receptor that is a sensor for viruses such as influenza A, Sendai virus, and flavivirus. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response.
Synonyms: Probable ATP-dependent RNA helicase DDX58, DEAD box protein 58, RIG-I-like receptor 1, RLR-1, Retinoic acid-inducible gene 1 protein, RIG-1, Retinoic acid-inducible gene I protein, RIG-I, DDX58
|Pathways||Activation of Innate immune Response, Hepatitis C|
Application DetailsProduct Details anti-DDX58 Antibody Target Details DDX58 Handling Images back to top
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.
|Restrictions||For Research Use only|
HandlingProduct Details anti-DDX58 Antibody Target Details DDX58 Application Details Images back to top
|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C,-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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