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ADD2 Products

(Adducin 2 (Beta) (ADD2))

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Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010].

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Featured ADD2 Categories

ADD2 Antibodies

High quality antibodies with extensive validation data.

ADD2 ELISA Kits

Reliable ELISA kits for a wide range of species.

ADD2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ADD2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (2)
Cat. No. ABIN7185800
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IF, ICC
Validations
  • (2)
Cat. No. ABIN6257742
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IF
Validations
  • (2)
Cat. No. ABIN3183187
Quantity 100 μL
Datasheet Datasheet

Recommended ADD2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380906
Quantity 96 tests
Datasheet Datasheet

Recommended ADD2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1305969
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3088423
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2715230
Quantity 20 μg
Datasheet Datasheet

Synonyms and alternative names related to ADD2

adducin 2 (ADD2), adducin 2 (beta) (add2), adducin 2 (add2), adducin 2 (beta) (Add2), adducin 2 (Add2), 2900072M03Rik, add97, ADDB, beta-ADD, si:dkey-202n14.5

Protein level used designations for ADD2

  • adducin 2 (beta)
  • beta-adducin
  • erythrocyte adducin subunit beta
  • beta-adducin-like
  • snoRNA MBII-396
  • adducin beta
  • adducin-63
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