(Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1))
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009].
Atsriku, Hoffmann, Moghaddam, Kumar, Surapaneni: "In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism." in: Xenobiotica; the fate of foreign compounds in biological systems, Vol. 45, Issue 6, pp. 465-80, (2015) (PubMed).
Aliases for AKR1B1 Proteins
aldo-keto reductase family 1 member B (AKR1B1) Proteins aldo-keto reductase family 1 member B (Akr1b1) Proteins aldo-keto reductase family 1, member B1 (aldose reductase) (AKR1B1) Proteins aldo-keto reductase family 1, member B1 (aldose reductase) S homeolog (akr1b1.S) Proteins aldo-keto reductase family 1, member B1 (aldose reductase) (akr1b1) Proteins ADR Proteins Akr1b3 Proteins Akr1b4 Proteins akr1b7 Proteins ALDR1 Proteins Aldr1 Proteins ALDRED Proteins Alr Proteins ALR-P-I Proteins ALR2 Proteins AR Proteins RATALDRED Proteins zgc:86611 Proteins