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anti-Human LKB1 Antibodies:
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Human Monoclonal LKB1 Primary Antibody for FACS, ELISA - ABIN969424
Al-Nashash, Fatoo, Mirza, Ahmed, Agrawal, Thakor, All: Spinal cord injury detection and monitoring using spectral coherence. in IEEE transactions on bio-medical engineering 2009
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Human Polyclonal LKB1 Primary Antibody for IF (p), IHC (p) - ABIN751573
Wang, Zhao, Yu, Feng, Zhang, Kou, Chu, Cui, Li, Zhang, Shen, Min: Regulation of steroid hormones and energy status with cysteamine and its effect on spermatogenesis. in Toxicology and applied pharmacology 2016
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Human Polyclonal LKB1 Primary Antibody for ELISA, WB - ABIN1002745
Boudeau, Baas, Deak, Morrice, Kieloch, Schutkowski, Prescott, Clevers, Alessi: MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. in The EMBO journal 2003
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Human Polyclonal LKB1 Primary Antibody for IHC (p), WB - ABIN1537707
Howard, Panchal, McCarthy, Ashworth: Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification. in Genes & development 2005
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Human Polyclonal LKB1 Primary Antibody for IHC (p), WB - ABIN966488
Jenne, Reimann, Nezu, Friedel, Loff, Jeschke, Müller, Back, Zimmer: Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. in Nature genetics 1998
Human Polyclonal LKB1 Primary Antibody for ICC, IF - ABIN4331209
Co, Iglesias, Celestino, Kwan, Mok, Schmandt, Lu: Loss of LKB1 in high-grade endometrial carcinoma: LKB1 is a novel transcriptional target of p53. in Cancer 2014
Human Polyclonal LKB1 Primary Antibody for FACS, IF - ABIN391350
Sohn, Jang, Campan, Weisenberger, Dickhout, Wang, Cho, Yates, Lucock, Chiang, Austin, Choi, Laird, Kim et al.: The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer ... in International journal of cancer. Journal international du cancer 2009
we have demonstrated a novel function of LKB1 in DNA damage response. Cancer cells lacking LKB1 are more susceptible to DNA damage-based therapy and, in particular, to drugs that further impair DNA repair, such as PARP (show COL11A2 Antibodies) inhibitors.
LKB1 overexpression inhibited apoptosis and activated autophagy of Eca109 cells following radiation treatment, as determined by flow cytometry and western blot analyses.
In this study, compound heterozygous variants of LKB1, c.890G > A/ c.1062C > G and del(exon1)/ c.1062C > G, were identified in two sporadic Chinese Peutz-Jeghers syndrome cases
By downregulating acetylated LKB1 protein via HERC2 (show HERC2 Antibodies), SIRT1 (show SIRT1 Antibodies) fine-tunes the crosstalk between endothelial and vascular smooth muscle cells to prevent adverse arterial remodeling and maintain vascular homeostasis
Data indicate that nesfatin-1/NUCB-2 (show NUCB2 Antibodies) enhanced migration, invasion and epithelial-mesenchymal transition (EMT (show ITK Antibodies)) in colon cancer cells through LKB1/AMPK (show PRKAA1 Antibodies)/TORC1 (show CRTC1 Antibodies)/ZEB1 (show ZEB1 Antibodies) pathways in vitro and in vivo.
STK11 sequence deletions and point mutations were found in 11 Chinese children with Peutz-Jeghers syndrome.
define a CIII-PI3K (show PIK3CA Antibodies)-regulated endosomal signalling platform from which LKB1 directs epithelial polarity, the dysregulation of which endows LKB1 with tumour-promoting properties
Structure of the complex of phosphorylated liver kinase B1 and 14-3-3zeta (show YWHAZ Antibodies) has been reported.
STK11 mutation is associated with Lung Adenocarcinoma.
Case Report: novel heterozygous mutation (c.426-448delCGTGCCGGAGAAGCGTTTCCCAG,p.S142SfsX13) in the STK11 gene causing PJS in a Chinese female without a Peutz-Jeghers syndrome family history.
The metabolic effects were associated with activation of the SIRT1 (show SIRT1 Antibodies)-LKB1-AMPK (show PRKAA1 Antibodies) signalling pathway in adipose tissue and liver.
Treg cells use LKB1 signalling to coordinate their metabolic and immunological homeostasis and to prevent apoptotic and functional exhaustion, thereby orchestrating the balance between immunity and tolerance
renal proximal tubule cell CB1R (show CNR1 Antibodies) contributes to the pathogenesis of obesity-induced renal lipotoxicity and nephropathy by regulating the liver kinase B1/AMP-activated protein kinase (show PRKAA2 Antibodies) signaling pathway
Results reveal an important role for Lkb1 in regulating cerebellar cortical size and foliation in a Hedgehog (show SHH Antibodies)-independent manner.
beige (show LYST Antibodies) adipocyte renaissance was governed by liver kinase b1 and histone deacetylase 4 (show HDAC5 Antibodies) in white adipocytes.
miR-17-92-dependent tuning of LKB1 levels regulates both the metabolic potential of Myc (show MYC Antibodies)+ lymphomas and tumor growth in vivo.
Findings indicate that the energy-sensing LKB1-AMPK (show PRKAA1 Antibodies) pathway regulates IGF1 (show IGF1 Antibodies) secretion in mouse primary hepatocytes, which in turn regulates activation of the IGF1R (show IGF1R Antibodies)-PKB (show AKT2 Antibodies) pathway.
These data suggest that nutrient availability dictates the mode of division and that LKB1-AMPK (show PRKAA1 Antibodies) mediates this nutrient-driven effect on intestinal epithelial stem cell proliferation.
this study identified the molecular mechanism of increased angiogenesis and tumor growth with LKB1 deficiency
These results suggest that although physiologic LKB1 expression exerts a potent pro-survival effect in lymphocytes, LKB1 inactivation nonetheless facilitates transformation of B, but not T, lymphocytes.
inactivation of zebrafish Lkb1 upregulates pyruvate dehydrogenase kinase 2 (show PDK2 Antibodies) expression and inactivates pyruvate dehydrogenase (show PDK2 Antibodies) complex by increasing phosphorylation of pyruvate dehydrogenase (show PDK2 Antibodies).
A critical role for LKB1 in regulating energy homeostasis at the whole-organism level in a vertebrate, is demonstrated.
Data suggest that programmed localization of Lkb1 could represent a novel mechanism for regulating the EIT during intestinal development in vertebrates.
Suggest that LKB1 plays an inhibitory role in endothelial cell proliferation and can promote endothelial senescence.
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
serine/threonine protein kinase 11
, serine/threonine kinase 11 (Peutz-Jeghers syndrome)
, Serine/threonine-protein kinase 11
, serine/threonine-protein kinase STK11
, serine/threonine kinase 11
, serine/threonine-protein kinase 11-like
, liver kinase B1
, polarization-related protein LKB1
, renal carcinoma antigen NY-REN-19
, serine/threonine-protein kinase 11
, serine/threonine-protein kinase LKB1
, LKB1 short isoform
, liver kinase B1 homolog
, egg and embryo kinase 1
, serine/threonine-protein kinase XEEK1
, serine/threonine-protein kinase stk11