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|Antigen||Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) Antibodies|
|Reactivity||Human, Monkey, Mouse (Murine), Pig (Porcine), Rat (Rattus) Alternatives|
|Conjugate||This SLC2A4 antibody is un-conjugated Alternatives|
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
|3 references available|
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Product Details anti-SLC2A4 AntibodyTarget Details SLC2A4 Application Details Handling References for anti-SLC2A4 antibody (ABIN113521) Images
|Specificity||This antibody recognizes Glucose Transporter 4 (GLUT4). It does not react with HEP G2 type Glucose Transporter in Human erythrocytes, Rat brain or other tissues that do not exhibit sensitivity to Insulin. Reacts with Monkey, Pig, Mouse and Rat.|
|Immunogen||A 12 amino acid peptide corresponding to the carboxyl terminus of the insulin regulatable glucose transporter conjugated to Keyhole Limpet Hemocyanin.|
|Plasmids, Primers & others|
Target Details SLC2A4Product Details anti-SLC2A4 Antibody Application Details Handling References for anti-SLC2A4 antibody (ABIN113521) Images back to top
|Alternative Name||GLUT4 / SLC2A4 (SLC2A4 Antibody Abstract)|
|Background||GLUT4 is the insulin-regulated glucose transporter found in adipose tissue and striated muscle, responsible for glucose disposal. The stimulation of glucose uptake by insulin requires translocation of the GLUT4 glucose transporter from intracellular storage sites to the cell surface. Activation of phosphatidylinositol-3-OH kinase (PI3K) is required for this trafficking event, but it is not sufficient to produce GLUT4 translocation. Human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface.Synonyms: GLUT-4, Glucose transporter 4, Glucose transporter type 4 insulin-responsive, Solute carrier family 2 facilitated glucose transporter member 4|
|Pathways||AMPK Signaling, Carbohydrate Homeostasis, Proton Transport, Brown Fat Cell Differentiation|
Application DetailsProduct Details anti-SLC2A4 Antibody Target Details SLC2A4 Handling References for anti-SLC2A4 antibody (ABIN113521) Images back to top
Western blot. Immunoprecipitation. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections: 10-20 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-SLC2A4 Antibody Target Details SLC2A4 Application Details References for anti-SLC2A4 antibody (ABIN113521) Images back to top
|Buffer||PBS containing 0.09 % Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
References for anti-SLC2A4 antibody (ABIN113521)Product Details anti-SLC2A4 Antibody Target Details SLC2A4 Application Details Handling Images back to top
Durante, Mustard, Park, Winder, Hardie: "Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles." in: American journal of physiology. Endocrinology and metabolism, Vol. 283, Issue 1, pp. E178-86, 2002
James, Strube, Mueckler: "Molecular cloning and characterization of an insulin-regulatable glucose transporter." in: Nature, Vol. 338, Issue 6210, pp. 83-7, 1989
Gangal, Magar: "Biological evaluation of crab meat (Scylla-serrata) in the rat." in: The British journal of nutrition, Vol. 21, Issue 1, pp. 1-6, 1970
ImagesProduct Details anti-SLC2A4 Antibody Target Details SLC2A4 Application Details Handling References for anti-SLC2A4 antibody (ABIN113521) back to top