CHCHD6 antibody (N-Term)

Catalog No. ABIN1077410

Product Details anti-CHCHD6 Antibody

Target: CHCHD6 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 (CHCHD6))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHCHD6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: CHCHD6 is predicted to not cross-react to other members of the CHCHD family.

Purification: Affinity chromatography purified via peptide column

Immunogen: Rabbit polyclonal CHCHD6 antibody was raised against a 17 amino acid peptide near the amino terminus of human CHCHD6.

Isotype: IgG

Application Details

Application Notes: CHCHD6 antibody can be used for detection of CHCHD6 by Western blot at 1 - 2 μg/mL.

Comment:

(NT) Coiled-coil-helix-coiled-coil-helix domain-containing protein 6

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C

Storage Comment: CHCHD6 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Expiry Date: 12 months

Target Details for CHCHD6

Target: CHCHD6 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 (CHCHD6))

Alternative Name: CHCHD6 (CHCHD6 Products)

Synonyms: CHCM1 antibody, PPP1R23 antibody, 0710001P09Rik antibody, 1700021B03Rik antibody, chchd6 antibody, hm:zeh0124 antibody, zgc:91802 antibody, coiled-coil-helix-coiled-coil-helix domain containing 6 antibody, coiled-coil-helix-coiled-coil-helix domain containing 6a antibody, CHCHD6 antibody, Chchd6 antibody, chchd6a antibody

Background: CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.
Synonyms: Coiled-coil-helix-coiled-coil-helix domain-containing protein 6, coiled coil helix cristae morphology 1, CHCM1, PPP1R23

Molecular Weight: 26 kDa (calculated)

Gene ID: 84303

NCBI Accession: NP_115719