SERPINA3 antibody

Catalog No. ABIN1105304

Product Details anti-SERPINA3 Antibody

Target: SERPINA3 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 3 (SERPINA3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SERPINA3 antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Alpha-1-antichymotrypsin (ACT).Aff. Const.:1 x 10e9 Moles/Liter

Purification: Protein A or Protein G Affinity Chromatography. Elution with 5 mM Citric Acid pH 2.5, neutralization with 50 mM Na2HPO4 at pH 8.8.

Immunogen: Human anti-Chymotrypsin (ACT)

Clone: N-a

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SERPINA3

Target: SERPINA3 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 3 (SERPINA3))

Alternative Name: alpha-1-Antichymotrypsin (ACT) (SERPINA3 Products)

Synonyms: SERPINA3-1 antibody, Pi2 antibody, AACT antibody, ACT antibody, GIG25 antibody, A1AT antibody, PI antibody, alpha-1-PI antibody, AAT antibody, Pi antibody, Spi1 antibody, SERPINA3-5 antibody, serpina3 antibody, serpin A3-5 antibody, serpin family A member 3 antibody, alpha-1-antiproteinase F precursor antibody, serpin family A member 1 antibody, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 antibody, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 antibody, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 L homeolog antibody, LOC396684 antibody, SERPINA3 antibody, LOC100008973 antibody, SERPINA1 antibody, Serpina1 antibody, SPIA5 antibody, serpina3.L antibody

Background: Chymotrypsins, such as Chymotrypsin C (also known as pancreatic Chymotrypsin or Chymotrypsin), are digestive enzymes that can perform proteolysis by cleaving peptides at the carboxyl side of tyrosine, tryptophan and phenylalanine, although over time they can also hydrolyze other amide bonds, especially those with leucine-donated carboxyls. Chymotrypsins cleave peptide bonds by attacking the un-reactive carbonyl group with a powerful nucleophile, the Serine 195 residue located in the active site of the enzyme, which momentarily becomes covalently bonded to the substrate to form an intermediate. Chymotrypsin C is synthesized in the pancreas by protein biosynthesis as a precursor called chymotrypsinogen that is enzymatically inactive, but becomes active as a three polypeptide molecule that is interconnected by disulfide bonds.Synonyms: AACT, Cell growth-inhibiting gene 24/25 protein, GIG24, GIG25, SERPINA3

Gene ID: 12

NCBI Accession: NP_001076

UniProt: P01011