Benzo[a]pyrenediol Epoxide antibody

Catalog No. ABIN1105513

Product Details anti-Benzo[a]pyrenediol Epoxide Antibody

Target: Benzo[a]pyrenediol Epoxide (BPDE)

Reactivity: Chemical

Host: Mouse

Clonality: Monoclonal

Conjugate: This Benzo[a]pyrenediol Epoxide antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Purification: Protein G

Clone: 8-00E-011

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for Benzo[a]pyrenediol Epoxide

Target: Benzo[a]pyrenediol Epoxide (BPDE)

Alternative Name: Benzo(a)pyrenediol-Epoxide (BPDE) (BPDE Products)

Target Type: Chemical

Background: A number of chemicals, including polycyclic aromatic hydrocarbons (PAHs), have been shown to bind to DNA. This DNA damage can occur both early and late in the malignant process, thereby acting as an initiator and assisting in the progression of tumors. PAHs are released into the environment following incomplete combustion of organic materials. The most common sources of PAHs are from smoking and from consuming broiled or grilled foods. Human exposure to PAHs comes from various occupational, environmental, dietary and medicinal sources. Benzo[a]pyrene is a representitive PAH. Antibodies to benzo[a]pyrenediol-epoxide modified DNA (BPDE-DNA) can be used to identify polycyclic aromatic hydrocarbon (PAH)-DNA adducts. Exposure to this group of compounds is believed to be carcinogenic.Synonyms: PAH, polycyclic aromatic hydrocarbon