Chips (N-Term) antibody
Reactivity: Mammalian
WB, IHC (p), IHC (fro), Func, EIA
Host: Mouse
Monoclonal
JNC1
unconjugated
-
- Target
- Chips
- Binding Specificity
- N-Term
-
Reactivity
- Mammalian
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- Un-conjugated
-
Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func), Enzyme Immunoassay (EIA)
- Specificity
- This antibody detects reacts the N-terminus of CHIPS.
- Purification
- Protein G purified
- Clone
- JNC1
- Isotype
- IgG1
-
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Concentration
- 0.1 mg/mL
- Buffer
- PBS, 0.01 % sodium azide, 0.1 % BSA
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Product should be stored at 2-8 °C. Under recommended storage conditions, product is stable for one year.
- Expiry Date
- 12 months
-
- Target
- Chips
- Synonyms
- NI36_09680 antibody, chemotaxis inhibitory protein antibody, NI36_RS09650 antibody
- Background
- The bacterial pathogen Staphylococcus aureus is insensitive to antimicrobial host defense peptides such as defensins, protegrins, platelet microbicidal proteins and bacteriocins. Staphylococci have developed various resistance mechanisms including those specific for bacteriocins and several host defense peptides. A protein belonging to the resistance mechanism of Staphylococcus aureus is known as CHIPS (Chemotaxis Inhibiting Protein of Staphylococcus aureus). CHIPS is a protein produced by Staphylococcus aureus that inhibits chemotaxis of neutrophils by blocking the Formyl Peptide Receptor (FPR) and C5a Receptor on neutrophils. CHIPS and antibodies against CHIPS can be useful for various experimental infection models of Staphylococcus aureus. Furthermore these reagents can be of help in studies on the role of FPR and C5a in inflammatory processes.
- Gene ID
- 2861356
- NCBI Accession
- YP_041409
- UniProt
- Q6GFB3
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