KCND3 antibody (N-Term)

Catalog No. ABIN1107930

Product Details anti-KCND3 Antibody

Target: KCND3 (Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 (KCND3))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCND3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: This antibody reacts with 73 kDa KCND3 protein.

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography on Protein A

Immunogen: Synthetic peptide derived from N-term domain of KCND3 protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore in distilled water.

Buffer: 0.1 M Tris, 0.1 M Glycine and 2 % Sucrose

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Prior to reconstitution store at-20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for KCND3

Target: KCND3 (Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 3 (KCND3))

Alternative Name: KCND3 (KCND3 Products)

Synonyms: KCND3 antibody, zgc:55306 antibody, wu:fi06g01 antibody, kv4.3 antibody, K(v)4.3 antibody, AW045978 antibody, Kncd3 antibody, Kv4.3 antibody, KCND3L antibody, KCND3S antibody, KSHIVB antibody, KV4.3 antibody, kcnd3-A antibody, xKv4.3 antibody, potassium voltage-gated channel subfamily D member 3 antibody, potassium voltage-gated channel, Shal-related subfamily, member 3 antibody, potassium channel, voltage gated Shal related subfamily D, member 3 antibody, potassium voltage-gated channel, Shal-related family, member 3 antibody, potassium channel, voltage gated Shal related subfamily D, member 3 L homeolog antibody, KCND3 antibody, kcnd3 antibody, Kcnd3 antibody, kcnd3.L antibody

Background: Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels. Potassium volgate-gated channel subfamily D member 3 (also knowns as Kv4.3) is a protein that in humans is encoded by the KCND3 gene. It contributes to the cardiac transient outward potassium current, the main contributing current to the repolarizing phase 1 of the cardiac action potential.Synonyms: Potassium voltage-gated channel subfamily D member 3, Voltage-gated potassium channel subunit Kv4.3

Gene ID: 3752

NCBI Accession: NP_004971

UniProt: Q9UK17