MAPT antibody (pThr181)

Catalog No. ABIN1108152

The Mouse Monoclonal anti-MAPT antibody (Clone 1A4) (ABIN1108152) specifically detects MAPT in WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for MAPT antibody (pThr181) (ABIN1108152)

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This MAPT antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 1A4

Product Details anti-MAPT Antibody

Binding Specificity: AA 177-187, pThr181

Sequence: Ala-Pro-Lys-Thr(p)-Pro-Pro-Ser-Ser-Gly-Glu-Cys

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Protein G affinity purified

Immunogen: KLH conjugated with a short peptide corresponding to the amino acid sequence 177-187 on the phosphorylated Tau protein

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Double distillated water is recommended to reconstitute the antibody.

Buffer: 0.01 M PBS pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20 °C.

Target Details for MAPT

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Alternative Name: MAPT / tau

Background: Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau

Gene ID: 9606

UniProt: P10636

Pathways: MAPK Signaling, Microtubule Dynamics, M Phase, Regulation of Cell Size