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STXBP1 antibody (C-Term, pThr574)
STXBP1
Reactivity: Human, Mouse, Rat
WB, IHC (fro), EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-STXBP1 Antibody
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Target
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STXBP1
(Syntaxin Binding Protein 1 (STXBP1))
Binding Specificity
All epitopes for STXBP1 antibodies
C-Term, pThr574
Reactivity
All reactivities for STXBP1 antibodies
Human, Mouse, Rat
Host
All hosts for STXBP1 antibodies
Rabbit
Clonality
All clonalities for STXBP1 antibodies
Polyclonal
Conjugate
All conjugates for STXBP1 antibodies
This STXBP1 antibody is un-conjugated
Application
All applications for STXBP1 antibodies
Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
Specificity
Reacts with Human 67 kDa Unc18-1 phosphorylated at Threonine 574.
Cross-Reactivity (Details)
Species reactivity (expected):Mouse, Rat. Species reactivity (tested):Human.
Purification
Affinity Chromatography on Protein A
Immunogen
Synthetic peptide derived from C-terminal domain of Human STXBP1 protein containing Phosphorylated Thr574
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Reconstitution
Restore in distilled water.
Buffer
0.1 M Tris, 0.1 M Glycine and 2 % Sucrose, None
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for STXBP1
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Target
STXBP1
(Syntaxin Binding Protein 1 (STXBP1))
Alternative Name
STXBP1 / UNC18A (STXBP1 Products )
Synonyms
MUNC18-1 antibody, NSEC1 antibody, P67 antibody, RBSEC1 antibody, UNC18 antibody, AI317162 antibody, AI326233 antibody, MMS10-G antibody, Ms10g antibody, Munc-18a antibody, Munc18-1 antibody, N-sec1 antibody, Rb-sec1 antibody, Sxtbp1 antibody, Unc18-1 antibody, Unc18h antibody, nsec1 antibody, fj43h10 antibody, stxbp1 antibody, wu:fj36d12 antibody, wu:fj43h10 antibody, zgc:114171 antibody, rop antibody, unc18 antibody, hunc18 antibody, rbsec1 antibody, munc18-1 antibody, MGC146482 antibody, ANC18HA antibody, NSEC1A antibody, Sec1 antibody, n-sec1 antibody, nSec1 antibody, rbSec1 antibody, rbSec1A antibody, rbSec1B antibody, UNC18A antibody, si:rp71-10d23.3 antibody, syntaxin binding protein 1 antibody, syntaxin binding protein 1a antibody, syntaxin binding protein 1 L homeolog antibody, syntaxin binding protein 1b antibody, STXBP1 antibody, Stxbp1 antibody, stxbp1a antibody, stxbp1 antibody, Tb09.160.0780 antibody, stxbp1.L antibody, stxbp1b antibody
Background
Unc18-1, 2, and 3 (syntaxin binding proteins 1-3, STXBP1-3, UNC18-a-c, MUNC18-1-3) are chaperone molecules that block syntaxin interactions with cognate SNARE (soluble NSF attachment protein (SNAP) receptor) proteins and regulate exocytosis. Unc18-1-3 mRNA is present in RBL-2H3 mast cells, mouse bone marrow derived mast cells (BMMC), and platelets. Unc18-1 Ser-313 is a protein kinase C phosphorylation site and Thr-574 is a cyclin-dependent kinase 5 phosphorylation site that regulates Unc18-1/syntaxin1A interactions. Unc18-1 is phosphorylated on Ser-313 in response to phorbol ester treatment in adrenal chromaffin cells. Unc18-2 colocalizes with syntaxin 3 at the apical plasma membrane of intestinal, proximal tubule, and collecting duct epithelial cells.Synonyms: N-Sec1, Syntaxin-binding protein 1, Unc-18 homolog, Unc-18-1, Unc-18A
Gene ID
6812
NCBI Accession
NP_001027392
Pathways
Synaptic Vesicle Exocytosis , Dicarboxylic Acid Transport
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