LGR5 antibody

Catalog No. ABIN1112906

Product Details anti-LGR5 Antibody

Target: LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LGR5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Purification: affinity purified

Isotype: IgG

Application Details

Application Notes: WB (1:1000-2000), IHC-P (1:200), ICC (1:50). Other applications have not been tested. The optimal dilutions should be determined by end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.

Preservative: Sodium azide, Thimerosal (Merthiolate)

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C after thawing (1 week). Aliquot and store at -20 °C for long term (at least one year). Avoid repeated freeze and thaw cycles.

Expiry Date: 12 months

Target Details for LGR5

Target: LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))

Alternative Name: Leucine-rich repeat-containing G-protein coupled receptor 5, LGR5 (LGR5 Products)

Synonyms: lgr5-a antibody, lgr5a antibody, FEX antibody, Gpr49 antibody, GPR49 antibody, GPR67 antibody, GRP49 antibody, HG38 antibody, leucine-rich repeat containing G protein-coupled receptor 5 L homeolog antibody, leucine rich repeat containing G protein coupled receptor 5 antibody, leucine rich repeat containing G protein-coupled receptor 5 antibody, lgr5.L antibody, Lgr5 antibody, LGR5 antibody

Background: Leucine-rich repeat-containing G-protein coupled receptor 5(LGR5), also known as GPR49, is a 907-amino acid 7-transmembrane protein, belongs to G Protein-Coupled Receptor. The differential expression of GPR49 between normal and tumor tissue was significant. GPR49 was upregulated in colon primary tumor tissues. In addition to colon tumors, GPR49 was also found to be upregulated in ovarian primary tumor tissues. Moreover, the expression level of GPR49 in colon and ovarian tumors increased in more advanced tumors suggesting a role for the receptor in tumor progression.

Pathways: WNT Signaling