Insulin antibody (INS)

Details for Product anti-INS Antibody No. ABIN111464
Antigen
  • ins1
  • xins
  • ins1-a
  • Insulin
  • IDDM2
  • ILPR
  • IRDN
  • MODY10
  • AA986540
  • Ins-2
  • InsII
  • Mody
  • Mody4
  • proinsulin
  • zgc:109842
  • insulin
  • insulin precursor
  • insulin II
  • preproinsulin
  • ins
  • PIN
  • INS
  • Ins
  • INS-IGF2
  • Ins2
Alternatives
anti-Human Insulin antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human
717
275
246
220
198
108
9
8
6
6
6
4
3
2
2
2
2
2
2
1
1
1
1
Host
Mouse
538
213
50
4
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Insulin antibody is un-conjugated
39
29
24
15
13
13
8
8
8
8
8
8
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
2
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
335
227
192
166
158
127
107
66
56
33
30
30
22
21
21
7
5
4
4
4
3
2
2
2
1
1
1
1
1
Options
Immunogen Human C-peptide conjugated to BSA
Clone C-PEP-01
Isotype IgG1
Specificity This antibody recognises C-peptide (also known as connecting peptide) a peptide released when proinsulin is cleaved to produce insulin. It can also be used to detect proinsulin.
Cross-Reactivity (Details) Also reacts to: Proinsulin
Purification Affinity chromatography on Protein A
Plasmids, Primers & others Plasmids, Primers & others Insulin products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Insulin (INS Antibody Abstract)
Background Synonyms: INS
Gene ID 3630
NCBI Accession NP_000198
UniProt P01308
Pathways NF-kappaB Signaling, RTK Signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
Application Notes Immunohistochemistry on frozen sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, pH 7.2 containing 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Product cited in: Meier, Köhler, Alkhatib, Sergi, Junker, Klein, Schmidt, Fritsch: "Beta-cell development and turnover during prenatal life in humans." in: European journal of endocrinology, Vol. 162, Issue 3, pp. 559-68, 2010 (PubMed).

Background publications Hilgert, Stolba, Kristofová, Stefanová, Bendlová, Lebl, Horejsí: "A monoclonal antibody applicable for determination of C-peptide of human proinsulin by RIA." in: Hybridoma, Vol. 10, Issue 3, pp. 379-86, 1991 (PubMed).

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