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TNFRSF10A antibody (Biotin)
TNFRSF10A
Reactivity: Human
FACS, IP, ICC, Func
Host: Mouse
Monoclonal
HS101
Biotin
Product Details anti-TNFRSF10A Antibody (Biotin)
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Target
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TNFRSF10A
(Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))
Reactivity
All reactivities for TNFRSF10A antibodies
Human
Host
All hosts for TNFRSF10A antibodies
Mouse
Clonality
All clonalities for TNFRSF10A antibodies
Monoclonal
Conjugate
All conjugates for TNFRSF10A antibodies
This TNFRSF10A antibody is conjugated to Biotin
Application
All applications for TNFRSF10A antibodies
Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC), Functional Studies (Func)
Specificity
Recognizes human TRAIL-R1.
Cross-Reactivity
Human
Cross-Reactivity (Details)
Does not cross-react with human TRAIL-R2, -R3 or -R4.
Purification
Purified from concentrated hybridoma tissue culture supernatant.
Purity
>95 % (SDS-PAGE)
Immunogen
Recombinant human TRAIL-R1 (DR4).
Clone
HS101
Isotype
IgG1
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
Lot specific
Buffer
In PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Short Term Storage: +4°C Long Term Storage: -20°C Stable for at least 1 year after receipt when stored at -20°C.
Expiry Date
12 months
Target Details for TNFRSF10A
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Target
TNFRSF10A
(Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))
Alternative Name
TRAIL-R1 (TNFRSF10A Products )
Synonyms
APO2 antibody, CD261 antibody, DR4 antibody, TRAILR-1 antibody, TRAILR1 antibody, TNFRSF10A antibody, TNF receptor superfamily member 10a antibody, tumor necrosis factor receptor superfamily member 26 antibody, tumor necrosis factor receptor superfamily, member 10a antibody, TNFRSF10A antibody, LOC510798 antibody
Background
TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
UniProt
O00220
Pathways
Apoptosis , Positive Regulation of Endopeptidase Activity
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