IFNA antibody

Catalog No. ABIN121866

Product Details anti-IFNA Antibody

Target: IFNA (Interferon alpha (IFNA))

Reactivity: Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFNA antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Functional Studies (Func), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography on protein G

Immunogen: Recombinant chicken Interferon alpha

Application Details

Application Notes: ELISA. Western Blot: This antibody cross reacts with IFN beta in western blots but does not show any cross reactivity with IFN gamma, this antibdoy detects a band of approximately 19 kDa. Functional Assays. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS

Preservative: Azide free

Storage: -20 °C

Storage Comment: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.

Expiry Date: 12 months

Target Details for IFNA

Target: IFNA (Interferon alpha (IFNA))

Alternative Name: Interferon alpha (IFN Alpha) (IFNA Products)

Synonyms: IFN-alphaO antibody, IFN-ALPHA-1 antibody, IFN1@ antibody, Ifa antibody, Ifa8 antibody, interferon alpha 16 antibody, interferon, alpha 1 antibody, interferon alpha antibody, interferon-alpha antibody, IFNA16 antibody, IFNA1 antibody, Ifna antibody, IFNA antibody

Background: The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken. A growing number of functional studies indicate similarities between chicken IFN and mammalian IFNI, revealing the conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes. Further research has shown that chIFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that recombinant chicken IFN acts as a potent antiviral agent.Synonyms: B Cell Interferon, IFN-alpha, IFNA, Interferon-alpha, Leukocyte Interferon, Type I Interferon

Pathways: JAK-STAT Signaling, TLR Signaling, Hepatitis C, Inflammasome