HSP90AA2 antibody (AA 289-300)

Catalog No. ABIN129685

Product Details anti-HSP90AA2 Antibody

Target: HSP90AA2 (Heat Shock Protein 90kDa alpha (Cytosolic), Class A Member 2 (HSP90AA2))

Binding Specificity: AA 289-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSP90AA2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Monkey, Chicken, Fruit Fly (Drosophila melanogaster)

Characteristics: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 289-300 of human Hsp90 protein.

Isotype: IgG

Application Details

Application Notes: This affinity purified antibody has been tested for use in ELISA and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 90 kDa in size corresponding to Hsp90 protein by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.24 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for HSP90AA2

Target: HSP90AA2 (Heat Shock Protein 90kDa alpha (Cytosolic), Class A Member 2 (HSP90AA2))

Alternative Name: Hsp 90 alpha (HSP90AA2 Products)

Synonyms: HSP90ALPHA antibody, HSPCA antibody, HSPCAL3 antibody, heat shock protein 90 alpha family class A member 2, pseudogene antibody, HSP90AA2P antibody

Background: This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Hsp90 is a member of the heat shock protein 90 family that functions as a molecular chaperone and has ATPase activity. Hsp90 family proteins are highly conserved between isoforms and species.  Several signal transduction pathways depend on Hsp90 function including erbB2, steroid hormone receptors (such as androgen, progesterone, glucocorticoid, and aryl-hydrocarbon), and hypoxia sensing (Hif1alpha).  Recent reports show that tumor cells are more sensitive to Hsp90 inhibition and that Hsp90 from tumor cells is more sensitive to small molecule inhibitors (eg 17AAG).  The mechanism of this differential sensitivity of normal versus tumor Hsp90 is not known (although mutation has been ruled out).  One possible mechanism may be differences in post-translational modification of tumor Hsp90.
Synonyms: HSP 86 antibody, HSP 86 antibody, Renal carcinoma antigen NY REN 38 antibody, Heat shock 90kDa protein 1 alpha antibody

Gene ID: 3320, 123678

UniProt: P07900