Anti-mouse T cell receptor monoclonal antibody reacts with the surface on all TCR bearing cells and does not react with receptors on TCR positive cells. It is thought that this clone may be specific for a determinant present on C The T cell receptors are present on murine CD4 CD8 thymocytes, peripheral T cells, intestinal CD8 intraepithelial lymphocytes and Thy 1 den- dritic epidermal cells in the skin Use of this antibody in conjunction with an anti-CD3 monoclonal antibody allows for accurate meas- urements of the mutually exclusive sub-populations of TCR and TCR bear- ing T cells. anti mouse TCR monoclonal antibody has also been used successfully for the characterization of murine intraepithelial lymphocytes.