DAZL antibody (AA 51-130)

Catalog No. ABIN1385600

Product Details anti-DAZL Antibody

Target: DAZL (Deleted in Azoospermia-Like (DAZL))

Binding Specificity: AA 51-130

Reactivity: Mouse, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DAZL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Cross-Reactivity: Mouse, Sheep

Predicted Reactivity: Human,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DAZL

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-DAZL antibody (ABIN1385600)

Zhang, Zhao, Zhang, Hao, Yu, Min, Li, Ma, Chen, Yi, Tang, Meng, Liu, Wang, Shen, Zhang: "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." in: Chemosphere, Vol. 194, pp. 147-157, (2018) (PubMed).

Target Details for DAZL

Target: DAZL (Deleted in Azoospermia-Like (DAZL))

Alternative Name: DAZL (DAZL Products)

Synonyms: DAZH antibody, DAZL1 antibody, DAZLA antibody, SPGYLA antibody, DAZL antibody, Xdazl antibody, dazh antibody, dazl1 antibody, dazla antibody, spgyla antibody, dazl-B antibody, dazl-a antibody, Daz-like antibody, Dazh antibody, Dazl1 antibody, Dazla antibody, Tpx-2 antibody, Tpx2 antibody, deleted in azoospermia like antibody, deleted in azoospermia-like antibody, deleted in azoospermia-like L homeolog antibody, DAZL antibody, dazl antibody, Dazl antibody, dazl.L antibody

Background:

Synonyms: DAZ homolog, DAZ like autosomal, DAZ-like autosomal, deleted in azoospermia-like, DAZH, DAZL 1, DAZL, DAZL_HUMAN, DAZL1, DAZLA, Deleted in azoospermia like 1, Deleted in azoospermia like, Deleted in azoospermia like autosomal, Deleted in azoospermia-like 1, Deleted in azoospermia-like, Germline specic RNA binding protein, MGC26406, Spermatogenesis gene on the Y like autosomal, SPGY like autosomal, SPGY-like-autosomal, SPGYLA, Tpx2.

Background: The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].

Gene ID: 1618