Lap1/Densin180 (AA 601-700) antibody
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- Target
- Lap1/Densin180
- Binding Specificity
- AA 601-700
- Reactivity
- Human
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Predicted Reactivity
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Densin180
- Isotype
- IgG
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- Application Notes
-
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
-
- Target
- Lap1/Densin180
- Background
-
Synonyms: Densin 180, Densin, Densin-180, densin180, DKFZp686I1147, KIAA1365, Lamin associated polypeptide 1, LAP 1, Leucine rich repeat containing 7, Leucine rich repeat containing protein 7, Leucine-rich repeat-containing protein 7,Lrrc 7, Lrrc7, LRRC7_HUMAN, MGC144918, OTTHUMP00000065336, OTTHUMP00000065337,OTTHUMP00000065338, Protein Lap 1, Protein lap1.
Background: Densin-180 is a synaptic transmembrane protein that is tightly associated with the postsynaptic density in CNS neurons and is postulated to function as a synaptic adhesion molecule. Densin-180 is a brain-specific momber of the O-sialoglycoprotein family which is highly concentrated at synapses along dendrites. The sequence of densin-180 contains 17 leucine-rich repeats, a sialomucin domain, an apparent transmembrane domain, and a PDZ (PSD-95, DIg, Z0-1) domain. The PDZ domain contributes to its binding to a-actinin. The intracellular portion of densin-180, CaMKIIa, interacts with a-actinin at distinct binding sites and, together, they form a ternary complex stabilized by multiple interactions.
- Gene ID
- 57554
- UniProt
- Q96NW7
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