SLC9A3 antibody (pSer552)

Catalog No. ABIN1387624

Product Details anti-SLC9A3 Antibody

Target: SLC9A3 (Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3))

Binding Specificity: pSer552

Reactivity: Rat, Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC9A3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human NHE-3 around the phosphorylation site of Ser552 [RG(p-S)LA](human Ser555)

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SLC9A3

Target: SLC9A3 (Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 (SLC9A3))

Alternative Name: NHE3 (SLC9A3 Products)

Synonyms: SLC9A3 antibody, 9030624O13Rik antibody, AI930210 antibody, NHE-3 antibody, NHE3 antibody, Nhe3 antibody, solute carrier family 9 member A3 antibody, sodium/hydrogen exchanger 3 antibody, Sodium/hydrogen exchanger 3 antibody, putative sodium/hydrogen exchanger 3 (nhe3) antibody, solute carrier family 9 (sodium/hydrogen exchanger), member 3 antibody, SLC9A3 antibody, LOC5570922 antibody, GL50803_102647 antibody, Smp_045680 antibody, Slc9a3 antibody

Background:

Synonyms: p-NHE-3, Sodium / Hydrogen Exchanger 3 phospho S552, Na+/H+ exchanger 3, NHE 3, NHE-3, NHE3, SL9A3_HUMAN, SLC9A 3, Slc9a3, Sodium/hydrogen exchanger 3, Sodium/hydrogen exchanger, apical epithelial, Solute carrier family 9 sodium/hydrogen exchanger, isoform 3, Solute carrier family 9 sodium/hydrogen exchanger, member 3, Solute carrier family 9 member 3, MGC126718, MGC126720.

Background: NHE-3 are integral membrane proteins that are expressed in most mammalian tissues, where they regulate intracellular pH and cell volume. NHEs mediate the transport of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+) ions. While NHE-1 is ubiquitously expressed, the NHE isoforms 2-8 have distinct tissue- and cell type-dependent expression and inhibitory characteristics. NHE-3 localizes to the apical membrane of renal proximal tubules where it is responsible for most of the sodium transport and fluid reabsorption. NHE-3 translocates to internal pools where it mediates natriuresis when blood pressure increases abruptly. NHE-3 is also expressed in the stomach and functions to protect the mucosa by secreting protons that diffuse into the mucous cells.

Pathways: Proton Transport