Kv1.6/KCNA6 antibody (AA 301-400)

Catalog No. ABIN1387941

Product Details anti-Kv1.6/KCNA6 Antibody

Target: Kv1.6/KCNA6 (KCNA6) (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 6 (KCNA6))

Binding Specificity: AA 301-400

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Kv1.6/KCNA6 antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Sheep,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Kv1.6

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Kv1.6/KCNA6

Target: Kv1.6/KCNA6 (KCNA6) (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 6 (KCNA6))

Alternative Name: Kv1.6 (KCNA6 Products)

Synonyms: Kv1.6 antibody, HBK2 antibody, KV1.6 antibody, MK1.6 antibody, potassium voltage-gated channel subfamily A member 6 antibody, potassium voltage-gated channel, shaker-related, subfamily, member 6 antibody, KCNA6 antibody, Kcna6 antibody

Background:

Synonyms: HBK 2, HBK2, Human brain potassium channel 2, KCNA 6, Kcna6, KCNA6_HUMAN, KV1.6, potassium voltage gated channel shaker related subfamily member 6, potassium voltage gated channel subfamily A member 6, Potassium voltage-gated channel subfamily A member 6, voltage gated potassium channel protein Kv1.6, Voltage gated potassium channel subunit Kv1.6, Voltage-gated potassium channel HBK2, Voltage-gated potassium channel subunit Kv1.6.

Background: Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha-subunits (KV alpha), which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KV beta subunits that modify the gating properties of the coexpressed KV alpha subunits. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels.

Gene ID: 3736

UniProt: Q09470