KCNA1 antibody (AA 281-350) (Biotin)

Catalog No. ABIN1392991

Product Details anti-KCNA1 Antibody (Biotin)

Target: KCNA1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))

Binding Specificity: AA 281-350

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNA1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Sheep,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Kv1.1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for KCNA1

Target: KCNA1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))

Alternative Name: Kv1.1 (KCNA1 Products)

Synonyms: AEMK antibody, EA1 antibody, HBK1 antibody, HUK1 antibody, KV1.1 antibody, MBK1 antibody, MK1 antibody, RBK1 antibody, KCNA1 antibody, AI840627 antibody, Kca1-1 antibody, Kv1.1 antibody, Mk-1 antibody, Shak antibody, mceph antibody, Kcna antibody, Kcpvd antibody, potassium voltage-gated channel subfamily A member 1 antibody, potassium voltage-gated channel, shaker-related subfamily, member 1 antibody, fragile site, aphidicolin type, common, fra(12)(q24) antibody, KCNA1 antibody, Kcna1 antibody, FRA12E antibody

Background:

Synonyms: Kv1.1 potassium channel, AEMK, EA1, Episodic ataxia with myokymia, HBK1, HUK1, Kca1 1, Kcna1, KCNA1_HUMAN, Kcpvd, KV1.1, MBK1, mceph, MGC124402, MGC126782, MGC138385, MK1, Potassium channel protein 1, Potassium voltage gated channel shaker related subfamily member 1, Potassium voltage gated channel subfamily A member 1, Potassium voltage-gated channel subfamily A member 1, RBK1, Shak, Shaker related subfamily member 1, Voltage gated potassium channel subunit Kv1.1, Voltage-gated K+ channel HuKI, Voltage-gated potassium channel HBK1, Voltage-gated potassium channel subunit Kv1.1.

Background: Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha-subunits (KV alpha), which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KV beta subunits that modify the gating properties of the coexpressed KV alpha subunits. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels.