GABRA6 antibody (AA 85-180) (Alexa Fluor 350)

Catalog No. ABIN1394937

Product Details anti-GABRA6 Antibody (Alexa Fluor 350)

Target: GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))

Binding Specificity: AA 85-180

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABRA6 antibody is conjugated to Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GABRA6/GABA A Receptor alpha 6

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GABRA6

Target: GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))

Alternative Name: GABRA6/GABA A Receptor alpha 6 (GABRA6 Products)

Synonyms: LOC100224835 antibody, GABRA6 antibody, Gabra-6 antibody, alpha6 antibody, si:dkey-217k23.1 antibody, zgc:73148 antibody, gamma-aminobutyric acid type A receptor alpha 6 subunit antibody, gamma-aminobutyric acid type A receptor alpha6 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6 antibody, gamma-aminobutyric acid (GABA) A receptor, alpha 6a antibody, Gabra6 antibody, GABRA6 antibody, gabra6a antibody

Background:

Synonyms: GABA A, GABA A Receptor alpha 6 polypeptide, GABA A receptor alpha 6, GABA A receptor subunit alpha 6, GABA subunit A receptor alpha 6, GABAA receptor subunit alpha-6, GABRA 6, GABRA6, Gamma aminobutyric acid A receptor alpha 6, Gamma aminobutyric acid GABA A receptor alpha 6, Gamma aminobutyric acid receptor subunit alpha 6, Gamma-aminobutyric acid receptor subunit alpha-6, GBRA6_HUMAN, MGC116903, MGC116904.

Background: GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA R alpha 1-6, GABAA R beta 1-3, GABAA R gamma 1-3, GABAA R gamma , GABAA R delta. The GABAB family is composed of GABAB R1 alpha and GABAB R1 beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.

Gene ID: 2559

UniProt: Q16445

Pathways: Synaptic Membrane