PDGF-AB Heterodimer (AA 81-180) antibody (Alexa Fluor 350)

Catalog No. ABIN1395489

Product Details

Target: PDGF-AB Heterodimer

Binding Specificity: AA 81-180

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PDGFAA + PDGFBB

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: PDGF-AB Heterodimer

Alternative Name: PDGFAA + PDGFBB

Synonyms: PDGF-A antibody, PDGF1 antibody, platelet derived growth factor subunit A antibody, PDGFA antibody

Background:

Synonyms: Becaplermin ,c sis ,c-sis ,FLJ12858 ,PDGF 1 ,PDGF 2 ,PDGF A ,PDGF A chain ,PDGF B ,PDGF B chain ,PDGF subunit B ,PDGF-2 ,Pdgfb ,PDGFB_HUMAN ,Platelet derived growth factor A chain precursor ,Platelet derived growth factor alpha polypeptide ,Platelet derived growth factor B chain precursor ,Platelet derived growth factor beta polypeptide simian sarcoma viral v-sis oncogene homolog ,Platelet derived growth factor beta polypeptide ,platelet-derived growth factor 2 ,Platelet-derived growth factor B chain ,Platelet-derived growth factor beta polypeptide ,Platelet-derived growth factor subunit B ,Platelet-derived growth factor, beta polypeptide oncogene SIS ,Proto-oncogene c-Sis ,SIS ,SSV ,v sis platelet derived growth factor beta polypeptide simian sarcoma viral oncogene homolog,

Background: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008].