Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2) (AA 401-497) antibody (Alexa Fluor 350)

Catalog No. ABIN1396346

Product Details

Target: Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2)

Binding Specificity: AA 401-497

Reactivity: Human, Virus

Host: Rabbit

Clonality: Polyclonal

Conjugate: Alexa Fluor 350

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Virus

Cross-Reactivity (Details): HHV4t2

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from HHV4t2 LMP2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2)

Alternative Name: EBV LMP2

Target Type: Viral Protein

Background:

Synonyms: EBV latent membrane protein 2A, Epstein Barr virus, HHV4, Human Herpesvirus 4, Latent membrane protein 2, LMP2, Terminal protein, EBV LMP2A, LMP2_EBVB9 , Latent membrane protein 2B, EBV LMP2B.

Background: Epstein Barr virus (EBV) is a member of the herpesvirus family and one of the most common human viruses. Most people become infected with EBV during their lives. Primary infections usually results in infectious mononucleosis (glandular fever) but the virus can also lay dormant in B lymphocytes and when reactivated become associated with more serious disease such as Burkitt's lymphoma, nasopharyngeal carcinoma and Hodgkin's disease. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.