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SASS6 antibody (AbBy Fluor® 488)

SASS6 Reactivity: Human, Mouse, Rat WB, IF (p) Host: Rabbit Polyclonal AbBy Fluor® 488
Catalog No. ABIN1401928
  • Target See all SASS6 Antibodies
    SASS6 (Spindle Assembly 6 Homolog (SASS6))
    Reactivity
    • 37
    • 17
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    Human, Mouse, Rat
    Host
    • 35
    • 2
    Rabbit
    Clonality
    • 37
    Polyclonal
    Conjugate
    • 14
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SASS6 antibody is conjugated to AbBy Fluor® 488
    Application
    • 34
    • 14
    • 12
    • 4
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SASS6
    Isotype
    IgG
    Top Product
    Discover our top product SASS6 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    SASS6 (Spindle Assembly 6 Homolog (SASS6))
    Alternative Name
    SASS6 (SASS6 Products)
    Synonyms
    SAS-6 antibody, SAS6 antibody, 2810453L12Rik antibody, RGD1306255 antibody, CG15524 antibody, DSAS-6 antibody, DSas-6 antibody, DSas6 antibody, Dmel\\CG15524 antibody, Dsas6 antibody, Sas-6 antibody, Sas6 antibody, dsas-6 antibody, sas6 antibody, wu:fb98c12 antibody, zgc:55668 antibody, SASS6 antibody, sass6.2 antibody, SAS-6 centriolar assembly protein antibody, Spindle assembly abnormal 6 antibody, spindle assembly 6 homolog L homeolog antibody, SAS-6 centriolar assembly protein L homeolog antibody, SASS6 antibody, Sass6 antibody, Sas-6 antibody, sass6.L antibody, sass6 antibody, sass6.2.L antibody
    Background

    Synonyms: HsSAS 6, HsSAS6, MGC119440, SAS 6, SAS6, SASS 6, Spindle assembly 6 homolog C. elegans, Spindle assembly 6 homolog, Spindle assembly abnormal protein 6 homolog, PJA2_HUMAN.

    Background: SAS-6 (spindle assembly abnormal protein 6 homolog, HsSAS-6) is a 657 amino acid protein encoded by the human gene SAS6. SAS-6 is a component of the centrosome that contains one PISA (present in SAS-6) domain. LK4, SAS-6, CPAP and other centriole related proteins are required at different stages of procentriole formation and were associated with different centriolar structures. SAS-6 associates only transiently with nascent procentrioles, whereas CEP135 and CPAP form a core structure within the proximal lumen of both parental and nascent centrioles. SAS-6 is necessary for procentriole formation in human cell lines and is localized asymmetrically next to the centriole at the onset of procentriole formation. SAS-6 levels oscillate during the cell cycle, it is degraded in mitosis starting at anaphase, and it accumulates again at the end of the following G1 phase. The anaphase-promoting complex targets SAS-6 for degradation by the 26S Proteasome, and a KEN box in the C-terminus of SAS-6 is necessary for its degradation. Increased SAS-6 levels promoted the formation of multiple procentrioles forming next to a single centriole.

    Gene ID
    163786
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