BCL11A antibody (AA 751-835) (HRP)

Catalog No. ABIN1409792

Product Details anti-BCL11A Antibody (HRP)

Target: BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))

Binding Specificity: AA 751-835

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL11A antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Ctip1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for BCL11A

Target: BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))

Alternative Name: Ctip1/BCL-11A (BCL11A Products)

Synonyms: 2810047E18Rik antibody, BCL-11A antibody, Ctip1 antibody, D930021L15Rik antibody, Evi9 antibody, Evi9a antibody, Evi9b antibody, Evi9c antibody, mKIAA1809 antibody, BCL11A-L antibody, BCL11A-S antibody, BCL11A-XL antibody, BCL11a-M antibody, CTIP1 antibody, EVI9 antibody, HBFQTL5 antibody, ZNF856 antibody, bcl11a antibody, wu:fi09f10 antibody, zgc:136898 antibody, B cell CLL/lymphoma 11A (zinc finger protein) antibody, B-cell CLL/lymphoma 11A antibody, B-cell CLL/lymphoma 11A L homeolog antibody, B-cell CLL/lymphoma 11Aa antibody, Bcl11a antibody, BCL11A antibody, bcl11a.L antibody, bcl11aa antibody

Background:

Synonyms: B cell CLL/lymphoma 11A zinc finger protein, B cell CLL/lymphoma 11A zinc finger protein isoform 2, B cell CLL/lymphoma 11A, B cell lymphoma/leukaemia 11A, B-cell CLL/lymphoma 11A, B-cell lymphoma/leukemia 11A, BC11A_HUMAN, BCL 11A, BCL-11A, BCL11A, BCL11A B cell CLL/lymphoma 11A zinc finger protein isoform 1, BCL11A L, BCL11A S, BCL11A XL, BCL11AL, BCL11AS, BCL11AXL, C2H2 type zinc finger protein, COUP TF interacting protein 1, COUP-TF-interacting protein 1, Ctip 1, CTIP1, Ecotropic viral integration site 9, Ecotropic viral integration site 9 homolog, Ecotropic viral integration site 9 protein, Ecotropic viral integration site 9 protein homolog, Evi 9, EVI-9, Evi9, FLJ10173, FLJ34997, HBFQTL5, KIAA1809, Zinc finger protein 856, ZNF856.

Background: Bcl-11a genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.

Pathways: Regulation of Cell Size