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IQCG antibody (Cy3)

IQCG Reactivity: Human, Mouse, Rat WB, IF (p) Host: Rabbit Polyclonal Cy3
Catalog No. ABIN1418255
  • Target See all IQCG Antibodies
    IQCG (IQ Motif Containing G (IQCG))
    Reactivity
    Human, Mouse, Rat
    Host
    • 20
    Rabbit
    Clonality
    • 20
    Polyclonal
    Conjugate
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IQCG antibody is conjugated to Cy3
    Application
    • 16
    • 12
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human IQCG
    Isotype
    IgG
    Top Product
    Discover our top product IQCG Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    IQCG (IQ Motif Containing G (IQCG))
    Alternative Name
    IQCG (IQCG Products)
    Synonyms
    2400003L07Rik antibody, RGD1311606 antibody, IQ motif containing G antibody, IQCG antibody, iqcg antibody, Iqcg antibody
    Background

    Synonyms: IQ domain containing protein G, IQ mot containing G, DKFZp434B227, FLJ11667, FLJ23571, FLJ37775, IQCG_HUMAN.

    Background: IQCG is a 443 amino acid protein containing one IQ domain. Widely distributed in nature, the IQ domain forms an amphiphilic seven-turn -helix capable of binding calmodulin in a Ca2+-independent manner. The level of intracellular calcium is tightly regulated in all eukaryotic cells. A modest increase in this level can result in a myriad of physiological responses, most of which are mediated by calmodulin (CaM), the universal calcium sensor. In acute T-lymphoid/myeloid leukemia, IQCG forms a complex with Nup98, an O-linked glycoprotein and a component of the nuclear pore complex. NUP98-IQCG complex bind co-activators and/or co-repressors, which suggest a role in transcriptional regulation.Nup98-IQCG complex inhibits 32Dcl3 cell apoptosis induced by Arabinofuranosylcytosine (Ara-C) and partially blocks granulocyte differentiation induced by G-CSF. IQCG exists as two isoforms due to alternatively splicing events.

    Gene ID
    84223
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