SERPINB3 + SERPINB4 antibody (HRP)
-
- Target
- SERPINB3 + SERPINB4
- Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- HRP
-
Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity
- Human
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human SERPINB3 (same as SERPINB4)
- Isotype
- IgG
-
-
- Application Notes
-
WB 1:300-5000
IHC-P 1:200-400 - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handling Advice
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
-
- Target
- SERPINB3 + SERPINB4
- Synonyms
- HsT1196 antibody, SCC antibody, SCCA-1 antibody, SCCA-PD antibody, SCCA1 antibody, T4-A antibody, serpin family B member 3 antibody, SERPINB3 antibody
- Background
-
Synonyms: HsT1196, Protein T4 A, Protein T4-A, SCC, SCCA PD, SCCA-1, SCCA1, SCCAPD, Serine or cysteine proteinase inhibitor clade B ovalbumin member 3, Serpin B3, Serpin peptidase inhibitor clade B ovalbumin member 3, SERPINB3, SPB3_HUMAN, Squamous cell carcinoma antigen 1, T4 A, T4A, SCCA 2, SCCA2, Leupin, Peptidase inhibitor 11, PI 11, PI-11, PI11, Protease inhibitor leucine serpin, SCCA-2, SCCA1, SCCA2/SCCA1 fusion protein, Serine or cysteine proteinase inhibitor, clade B ovalbumin, member 4, Serpin B4, Serpin peptidase inhibitor, clade B ovalbumin, member 4, SERPINB 4, SERPINB4, SPB4_HUMAN, Squamous cell carcinoma antigen 1, Squamous cell carcinoma antigen 2.
Background: Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine prote-ases, such as neutrophil elastase.SCCA is transcribed by two nearly identical genes (SCCA1 and SCCA2), and is mainly produced as SCCA1. The human SCCA1 gene encodes a 390 amino acid protein that was originally isolated from a metastatic cervical squamous cell carcinoma. SCCA2 may act as a protease inhibitor to modulate the host immune response against tumor cells.
- Gene ID
- 6317
-
