ANGEL2 antibody (HRP)

Catalog No. ABIN1422274

Product Details anti-ANGEL2 Antibody (HRP)

Target: ANGEL2 (Angel Homolog 2 (ANGEL2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANGEL2 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ANGEL2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ANGEL2

Target: ANGEL2 (Angel Homolog 2 (ANGEL2))

Alternative Name: ANGEL2 (ANGEL2 Products)

Synonyms: MGC115586 antibody, 2610307I21Rik antibody, 5730410O10Rik antibody, AI845692 antibody, D1Ertd396e antibody, D1Ertd654e antibody, RGD1305056 antibody, KIAA0759L antibody, angel homolog 2 antibody, angel homolog 2 S homeolog antibody, ANGEL2 antibody, angel2.S antibody, angel2 antibody, Angel2 antibody

Background:

Synonyms: NGE2_HUMAN, Angel homolog 2, angel2, Protein angel homolog 2.

Background: ANGEL2 is a 544 amino acid protein that belongs to the CCR4/nocturin family and exists as two alternatively spliced isoforms. The CCR4 family of proteins are 3_5_-deadenylases that function in the first step of the degradation of poly(A) mRNA. The CCR4 family most likely displays both RNA and ssDNA substrate preferences, thereby implicating a potential role in many regulatory processes. The ANGEL2 gene maps to human chromosome 1 (1q32.3), which is the largest human chromosome spanning about 260 million base pairs and making up 8 % of the human genome. Chromosome 1 contains about 3,000 genes, and considering the great number of genes there are also a large number of diseases associated with it. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons disease, Gaucher disease and Usher syndrome are also associated with chromosome 1.

Gene ID: 90806