FZD9 antibody (AA 185-270) (PE)

Catalog No. ABIN1428465

Product Details anti-FZD9 Antibody (PE)

Target: FZD9 (Frizzled Family Receptor 9 (FZD9))

Binding Specificity: AA 185-270

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FZD9 antibody is conjugated to PE

Application: Western Blotting (WB)

Specificity: This antibody may have slight cross reactivity with Frizzled 10.

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Frizzled 9/CD349

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FZD9

Target: FZD9 (Frizzled Family Receptor 9 (FZD9))

Alternative Name: Frizzled 9/CD349 (FZD9 Products)

Synonyms: CD349 antibody, FZD3 antibody, mfz9 antibody, Fz-9 antibody, cFz-9 antibody, fz11 antibody, fzd9 antibody, fzx antibody, hm:zehl0603 antibody, zehl0603 antibody, zg11 antibody, frizzled class receptor 9 antibody, frizzled class receptor 9a antibody, frizzled class receptor 9b antibody, FZD9 antibody, Fzd9 antibody, fzd9a antibody, fzd9b antibody

Background:

Synonyms: FZD3, CD349, Frizzled-9, Fz-9, hFz9, FzE6, FZD9

Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Gene ID: 8326

UniProt: O00144

Pathways: WNT Signaling