GABRE antibody (PE)

Catalog No. ABIN1429630

This Rabbit Polyclonal antibody specifically detects GABRE in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GABRE antibody (PE) (ABIN1429630)

Target: GABRE (gamma-aminobutyric Acid (GABA) A Receptor, epsilon (GABRE))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABRE antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-GABRE Antibody (PE)

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GABARE/GABA Receptor Epsilon

Isotype: IgG

Application Details

Application Notes: FCM: 1:20-100
Optimal working dilution should be determined by the investigator.

Comment:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4 °C

Expiry Date: 12 months

Target Details for GABRE

Target: GABRE (gamma-aminobutyric Acid (GABA) A Receptor, epsilon (GABRE))

Background:

GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA R Alpha 1-6, GABAA R Beta 1-3, GABAA R Gamma 1-3, GABAA R Delta, GABAA R Epsilon, GABAA R Zeta 1 and GABAA R Zeta 2. The GABAB family is composed of GABAB R1 Alpha and GABAB R1 Beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.

Subcellular location: Extracellular

Synonyms: GABAA receptor epsilon, GABAA receptor subunit epsilon, Gabre, Gamma aminobutyric acid GABA A receptor epsilon, Gamma aminobutyric acid receptor subunit epsilon, Gamma-aminobutyric acid receptor subunit epsilon, GBRE_HUMAN.

Pathways: Synaptic Membrane