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FLT3 antibody (N-Term)
FLT3
Reactivity: Human, Mouse
WB, IF, EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-FLT3 Antibody
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Target
See all FLT3 Antibodies
FLT3
(Fms-Related tyrosine Kinase 3 (FLT3))
Binding Specificity
All epitopes for FLT3 antibodies
N-Term
Reactivity
All reactivities for FLT3 antibodies
Human, Mouse
Host
All hosts for FLT3 antibodies
Rabbit
Clonality
All clonalities for FLT3 antibodies
Polyclonal
Conjugate
All conjugates for FLT3 antibodies
This FLT3 antibody is un-conjugated
Application
All applications for FLT3 antibodies
Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
Cross-Reactivity (Details)
Species reactivity (tested):Human, Mouse.
Purification
Affinity chromatography purified via peptide column
Immunogen
18 amino acid synthetic peptide near the center of Human FLT3
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
1.0 mg/mL
Buffer
PBS containing 0.02 % Sodium Azide as preservative
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for FLT3
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Target
FLT3
(Fms-Related tyrosine Kinase 3 (FLT3))
Alternative Name
CD135 / FLT3 (FLT3 Products )
Synonyms
FLT3 antibody, B230315G04 antibody, CD135 antibody, Flk-2 antibody, Flk2 antibody, Flt-3 antibody, Ly72 antibody, wmfl antibody, FLK-2 antibody, FLK2 antibody, STK1 antibody, fms related tyrosine kinase 3 antibody, FMS-like tyrosine kinase 3 antibody, fms-related tyrosine kinase 3 antibody, FLT3 antibody, Flt3 antibody
Background
FLT3 is a member of the class III receptor tyrosine kinase family and its internal tandem duplication (ITD) is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. It is a membrane bound glycosylated protein that is expressed primarily in early hematopoietic progenitor cells. Upon binding its ligand FL, FLT3 activates multiple signaling pathways including the PI3K/Akt and Ras/MEK/MAPK pathways. In cells expressing FLT3-ITD, these pathways are constitutively on, resulting in abnormal cell growth and anti-apoptotic activity.Synonyms: FL cytokine receptor, STK1, Stem cell tyrosine kinase 1, Tyrosine-protein kinase receptor FLT3
Molecular Weight
109 kDa
Gene ID
2322
NCBI Accession
NP_004110
Pathways
RTK Signaling
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