zc3h9 antibody, gpatc6 antibody, gpatch6 antibody, zc3hdc9 antibody, GPATC6 antibody, GPATCH6 antibody, KIAA1847 antibody, ZC3H9 antibody, ZC3HDC9 antibody, ZIP antibody, 1500006I01Rik antibody, BC021513 antibody, RGD1310801 antibody, zgc:63730 antibody, zinc finger CCCH-type and G-patch domain containing antibody, zinc finger, CCCH-type with G-patch domain L homeolog antibody, zinc finger, CCCH-type with G-patch domain antibody, zinc finger, CCCH-type with G patch domain antibody, ZGPAT antibody, zgpat.L antibody, zgpat antibody, Zgpat antibody
Background
The Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT), is a transcriptional repressor that regulates several cellular pathways including EGFR pathways that are involved in cell proliferation, migration and survival. ZGPAT recruits the Mi-2/NuRD complex and represses the expression of EGFR. ZGPAT is down-regulated in breast carcinomas and its expression is negatively correlated with that of EGFR, suggesting that it may be a potential target for breast cancer therapy. Multiple isoforms of ZGPAT are known to exist, including sZIP, which binds to the Mi-2/NuRD complex but lacks the DNA binding component of full-length ZGPAT, thereby antagonizing transcription repression and growth inhibition by ZGPAT.Synonyms: G patch domain-containing protein 6, GPATC6, GPATCH6, KIAA1847, ZC3H9, ZC3HDC9, Zinc finger CCCH domain-containing protein 9, Zinc finger CCCH-type with G patch domain-containing protein