Choline Acetyltransferase antibody (AA 334-383)

Catalog No. ABIN1453134

The Rabbit Polyclonal anti-Choline Acetyltransferase antibody (ABIN1453134) specifically detects Choline Acetyltransferase in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Choline Acetyltransferase antibody (AA 334-383) (ABIN1453134)

Target: Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Choline Acetyltransferase antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Choline Acetyltransferase Antibody

Binding Specificity: AA 334-383

Purpose: Choactase Antibody

Specificity: Choactase Polyclonal Antibody detects endogenous levels of Choactase protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human Choactase. AA range:334-383

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Choline Acetyltransferase

Target: Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))

Alternative Name: Choactase

Background:

Synonyms: CHAT; Choline O-acetyltransferase; CHOACTase; ChAT; Choline acetylase

Background: This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010],

Gene Name: CHAT

Protein Name: Choline O-acetyltransferase

Molecular Weight: 82 kDa

Gene ID: 1103

OMIM: 118490

UniProt: P28329

Pathways: Skeletal Muscle Fiber Development