PFKM antibody (AA 320-369)

Catalog No. ABIN1453764

The Rabbit Polyclonal anti-PFKM antibody (ABIN1453764) specifically detects PFKM in WB, IHC, ELISA and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PFKM antibody (AA 320-369) (ABIN1453764)

Target: PFKM (phosphofructokinase, Muscle (PFKM))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PFKM antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-PFKM Antibody

Binding Specificity: AA 320-369

Purpose: PFKM Antibody

Specificity: PFKM Polyclonal Antibody detects endogenous levels of PFKM protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human PFK-1. AA range:320-369

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for PFKM

Target: PFKM (phosphofructokinase, Muscle (PFKM))

Alternative Name: PFK-1

Background:

Synonyms: PFKM, PFKX, 6-phosphofructokinase, muscle type, Phosphofructo-1-kinase isozyme A, PFK-A, Phosphofructokinase-M, Phosphofructokinase 1, Phosphohexokinase

Background: Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type.This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009],

Gene Name: PFKM

Protein Name: 6-phosphofructokinase muscle type

Molecular Weight: 85 kDa

Gene ID: 5213

OMIM: 610681

UniProt: P08237

Pathways: Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Warburg Effect