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TOPBP1 antibody (pSer1159)

TOPBP1 Reactivity: Human DB Host: Rabbit Polyclonal RB36342 unconjugated
Catalog No. ABIN1539690
  • Target See all TOPBP1 Antibodies
    TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))
    Binding Specificity
    • 13
    • 12
    • 8
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer1159
    Reactivity
    • 50
    • 14
    • 9
    Human
    Host
    • 47
    • 3
    • 2
    Rabbit
    Clonality
    • 50
    • 2
    Polyclonal
    Conjugate
    • 25
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TOPBP1 antibody is un-conjugated
    Application
    • 28
    • 28
    • 14
    • 9
    • 4
    • 4
    • 2
    • 1
    • 1
    Dot Blot (DB)
    Predicted Reactivity
    M
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This TOPBP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1159 of human TOPBP1.
    Clone
    RB36342
    Isotype
    Ig Fraction
    Top Product
    Discover our top product TOPBP1 Primary Antibody
  • Application Notes
    DB: 1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Phospho-TOPBP1-S1159 Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the Phospho-TOPBP1-S1159 Antibody at -20 °C.
    Expiry Date
    6 months
  • Liu, Graves, Scott, Li, Lin: "Akt switches TopBP1 function from checkpoint activation to transcriptional regulation through phosphoserine binding-mediated oligomerization." in: Molecular and cellular biology, Vol. 33, Issue 23, pp. 4685-700, (2013) (PubMed).

  • Target
    TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))
    Alternative Name
    TOPBP1 (TOPBP1 Products)
    Synonyms
    RGD1562949 antibody, TOPBP1 antibody, cut5 antibody, F2P24.3 antibody, F2P24_3 antibody, meiosis defective 1 antibody, TOP2BP1 antibody, 1110031N14Rik antibody, 2810429C13Rik antibody, AI256758 antibody, D430026L04Rik antibody, mKIAA0259 antibody, TopBP1-A antibody, TopBP1-B antibody, Xmus101 antibody, XtopBP antibody, mus101 antibody, top2bp1 antibody, DNA topoisomerase II binding protein 1 antibody, topoisomerase (DNA) II binding protein 1 antibody, dna topoisomerase ii binding protein 1 (IC) antibody, transcription coactivator antibody, DNA topoisomerase II binding protein 1 L homeolog antibody, Topbp1 antibody, topbp1 antibody, TOPBP1 antibody, MEI1 antibody, topbp1.L antibody
    Background
    This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.
    Molecular Weight
    170679
    Gene ID
    11073
    NCBI Accession
    NP_008958
    UniProt
    Q92547
    Pathways
    Chromatin Binding
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