VEGFR2/CD309 antibody (Soluble)

Catalog No. ABIN1589803

This Rabbit Polyclonal antibody specifically detects VEGFR2/CD309 in WB. It exhibits reactivity toward Human.

Quick Overview for VEGFR2/CD309 antibody (Soluble) (ABIN1589803)

Target: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VEGFR2/CD309 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-VEGFR2/CD309 Antibody

Binding Specificity: Soluble

Purpose: Rabbit Anti-Human VEGFR-2/KDR (Peptide), soluble Polyclonal Antibody

Specificity: Peptide: CGRETILDHSAEAVGMP.

Characteristics: Chromosomal location: 4q11-q12
Produced from sera of rabbits immunised with a peptide of the C-terminal end of native human soluble VEGFR-2/KDR (CGRETILDHSAEAVGMP).

Purification: Anti-human soluble VEGFR-2/KDR was purified by affinity chromatography with immobilized Protein A.

Immunogen: Peptide: CGRETILDHSAEAVGMP.

Isotype: IgG

Application Details

Application Notes: Western Blot: Use 1-5 μg/mL

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Handling Advice: Centrifuge vial prior to opening.

Storage: 4 °C,-20 °C

Storage Comment: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Expiry Date: 24 months

Target Details for VEGFR2/CD309

Target: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Alternative Name: VEGFR-2/KDR

Background:

Synonyms: soluble vascular endothelial growth factor receptor-2 , soluble KDR, soluble FLK1, soluble CD309, VEGF receptor 2, sKDR

Description: VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. Human VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.

Gene ID: 3791

NCBI Accession: NM_002253, NP_002244

UniProt: P35968

Pathways: RTK Signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling