GSK3 alpha antibody (AA 409-483)

Catalog No. ABIN1680131

The Rabbit Polyclonal anti-GSK3 alpha antibody is suitable to detect GSK3 alpha in samples from Human. It has been validated for WB and IF.

Quick Overview for GSK3 alpha antibody (AA 409-483) (ABIN1680131)

Target: GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSK3 alpha antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-GSK3 alpha Antibody

Binding Specificity: AA 409-483

Sequence: LGTQLPNNRP LPPLFNFSAG ELSIQPSLNA ILIPPHLRSP AGTTTLTPSS QALTETPTSS DWQSTDATPT LTNSS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 409-483 of human GSK3alpha (NP_063937.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:1000,IF,1:20 - 1:100

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GSK3 alpha

Target: GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))

Alternative Name: GSK3A

Background: This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease.,GSK3 alpha,GSK3A,Epigenetics & Nuclear Signaling,Translation Control,Regulation of eIF4 and p70 S6 Kinase,Signal Transduction,Kinase,Serine/threonine kinases,PI3K-Akt Signaling Pathway,mTOR Signaling Pathway,ErbB-HER Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Inhibition of Apoptosis,Cell Cycle,Cell Adhesion,Protein folding,Wnt/β-Catenin Signaling Pathway,ESC Pluripotency and Differentiation,Endocrine & Metabolism,Insulin Receptor Signaling Pathway,Endocrine and metabolic diseases,Diabetes,Immunology & Inflammation,B Cell Receptor Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Stem Cells,Cardiovascular,Heart,Hypertrophy,Akt downstream targets,GSK3A

Molecular Weight: 50 kDa

Gene ID: 2931

UniProt: P49840

Pathways: PI3K-Akt Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, BCR Signaling, Warburg Effect