Ficolin 2 antibody (AA 231-313) (AbBy Fluor® 647)
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- Target See all Ficolin 2 (FCN2) Antibodies
- Ficolin 2 (FCN2) (Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin) (FCN2))
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Binding Specificity
- AA 231-313
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Ficolin 2 antibody is conjugated to AbBy Fluor® 647
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Cross-Reactivity
- Human
- Predicted Reactivity
- Mouse,Rat
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Ficolin 2/Ficolin B
- Isotype
- IgG
- Top Product
- Discover our top product FCN2 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Ficolin 2 (FCN2) (Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin) (FCN2))
- Alternative Name
- Ficolin 2/Ficolin B (FCN2 Products)
- Synonyms
- EBP-37 antibody, FCNL antibody, P35 antibody, ficolin-2 antibody, Fcn2 antibody, FCN1 antibody, fcn2 antibody, fcn2.S antibody, ficolin 2 antibody, ficolin B antibody, ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) antibody, ficolin 2 L homeolog antibody, FCN2 antibody, Fcnb antibody, fcn2.L antibody
- Background
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Synonyms: 37 kDa elastin-binding protein, Collagen/fibrinogen domain containing protein 2, Collagen/fibrinogen domain-containing protein 2, EBP 37, EBP-37, EBP37, FCN 2, Fcn2, FCN2_HUMAN, FCNL, Ficolin collagen/fibrinogen domain containing lectin 2 hucolin, Ficolin B, Ficolin beta, Ficolin-2, Ficolin-B, Ficolin-beta, Ficolin2, Hucolin, L ficolin, L-ficolin, OTTHUMP00000022518, P35, RP11 263F14.2, Serum lectin p35.
Background: Ficolin B is the designation in mouse and rat of a protein also known as L-ficolin, ficolin-2, collagen/fibrinogen domain-containing protein 2, serum lectin p35, EBP-37 or hucolin. Ficolin B is a 313 amino acid member of the ficolin lectin family. It is a secreted innate immunity pattern recognition molecule expressed in liver and plasma that forms a disulfide-linked homopolymer. This extensive N-terminal disulfide bridge formation can lead to a functional dodecamer polypeptide. Ficolin B binds to DNA ligands expressed by late apoptotic and necrotic cells to increase attachment and engulfment. Variation in ficolin B concentrations amongst individuals is associated with polymorphisms in the promoter and structural portion of the FCN2 gene. In patients with Beht's disease (BD), there exists a significant difference in allele frequency for FCN2 gene single nucleotide polymorphisms (SNPs) within the -557 and -64 promoter sites within HLA-B51 positive and HLA-B51 negative subgroups.
- Gene ID
- 2220
- Pathways
- Complement System
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