PAG1 antibody (AA 331-432) (Biotin)

Catalog No. ABIN1700376

The Biotin-conjugated Rabbit Polyclonal anti-PAG1 antibody (ABIN1700376) specifically detects PAG1 in WB, IHC (p) and IHC (fro). The antibody is reactive with Human samples.

Quick Overview for PAG1 antibody (AA 331-432) (Biotin) (ABIN1700376)

Target: PAG1 (phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAG1 antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-PAG1 Antibody (Biotin)

Binding Specificity: AA 331-432

Purpose: PAG1 Polyclonal Antibody, Biotin Conjugated

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PAG1

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for PAG1

Target: PAG1 (phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1))

Alternative Name: PAG1

Background:

Synonyms: CBP, PAG, Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Csk-binding protein, Transmembrane adapter protein PAG, Transmembrane phosphoprotein Cbp, PAG1

Background: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.

Gene ID: 55824

UniProt: Q9NWQ8

Pathways: p53 Signaling, TCR Signaling, EGFR Signaling Pathway, CXCR4-mediated Signaling Events