FZD3 antibody (Frizzled Family Receptor 3) (AA 150-200) (Cy5)

Details for Product anti-FZD3 Antibody No. ABIN1704293
Antigen
Epitope
AA 150-200
15
15
11
10
9
7
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
106
58
26
2
2
2
2
2
2
2
2
1
Host
Rabbit
91
9
6
4
Clonality
Polyclonal
Conjugate
This FZD3 antibody is conjugated to Cy5
7
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
68
56
24
23
14
12
5
4
4
2
2
1
Options
Immunogen KLH conjugated synthetic peptide derived from human FZD3/Frizzled 3
Isotype IgG
Purification Purified by Protein A.
Antigen
Alternative Name FZD3/Frizzled 3 (FZD3 Antibody Abstract)
Background

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subcellular location: Extracellular

Synonyms: Fz-3, Frizzled-3, hFz3, FZD3

Gene ID 7976
UniProt Q9NPG1
Pathways WNT Signaling, Tube Formation
Application Notes IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C
Expiry Date 12 months