ERBB4 antibody (pTyr1258) (Cy5)

Catalog No. ABIN1705048

This Rabbit Polyclonal antibody specifically detects ERBB4 in IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for ERBB4 antibody (pTyr1258) (Cy5) (ABIN1705048)

Target: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERBB4 antibody is conjugated to Cy5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-ERBB4 Antibody (Cy5)

Binding Specificity: pTyr1258

Purpose: Phospho-HER4 (Tyr1258) Polyclonal Antibody, Cy5 Conjugated

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit,GuineaPig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human HER4 around the phosphorylation site of Tyr1258 [PD(p-Y)LQ ]

Isotype: IgG

Application Details

Application Notes: IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ERBB4

Target: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Alternative Name: HER4

Background:

Synonyms: ErbB 4 phospho Y1258, p-ErbB 4 phospho Y1258, ErbB4, HER 4, HER4, Avian erythroblastic leukemia viral oncogene homolog 4, Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4, MGC138404, P180erbB4, Receptor protein tyrosine kinase erbB 4 precursor, Receptor tyrosine protein kinase erbB 4,Tyrosine kinase type cell surface receptor HER4, v erb a avian erythroblastic leukemia viral oncogene homolog like 4, v erb a erythroblastic leukemia viral oncogene homolog 4, Verba avian erythroblastic leukemia viral oncogene homolog like 4, Verba erythroblastic leukemia viral oncogene homolog 4, VERBB2.

Background: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].

Gene ID: 2066

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway