NIPBL antibody (AA 2651-2805) (HRP)

Catalog No. ABIN1711717

Product Details anti-NIPBL Antibody (HRP)

Target: NIPBL (Nipped-B like Protein (NIPBL))

Binding Specificity: AA 2651-2805

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NIPBL antibody is conjugated to HRP

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IDN3

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NIPBL

Target: NIPBL (Nipped-B like Protein (NIPBL))

Alternative Name: IDN3 (NIPBL Products)

Synonyms: CDLS antibody, CDLS1 antibody, IDN3 antibody, IDN3-B antibody, Scc2 antibody, SCC2W antibody, scc2 antibody, nipbl antibody, scc2-2 antibody, NIPBL antibody, nipbla antibody, wu:fi33d08 antibody, 4921518A06Rik antibody, 4933421G18Rik antibody, C79399 antibody, Idn3 antibody, NIPBL, cohesin loading factor antibody, Nipped-B homolog-like antibody, NIPBL, cohesin loading factor S homeolog antibody, nipped-B homolog b (Drosophila) antibody, nipped-B-like protein A antibody, Nipped-B homolog (Drosophila) antibody, NIPBL antibody, NIPBLL antibody, nipbl.S antibody, LOC427439 antibody, nipblb antibody, LOC100164947 antibody, nipbl antibody, Nipbl antibody

Background:

Synonyms: CDLS, Colon tumor susceptibility 2, Delangin, DKFZp434L1319, FLJ11203, FLJ12597, FLJ13354, FLJ13648, FLJ44854, IDN 3, IDN 3 protein, IDN 3 protein isoform A, IDN 3 protein isoform B, IDN 3B, IDN3 B, IDN3 protein, IDN3 protein isoform A, IDN3 protein isoform B, IDN3B, Mis 4, Mis4, Nipbl, NIPBL_HUMAN, Nipped B homolog Drosophila, Nipped B homolog, Nipped B like, Nipped B like protein, Nipped-B-like protein, Scc 2, SCC 2 homolog, Scc2, SCC2 homolog, Sister chromatid cohesion protein Mis4.

Background: This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Pathways: Sensory Perception of Sound, Stem Cell Maintenance