TNFSF13 antibody (AA 196-210)

Catalog No. ABIN1731914

Product Details anti-TNFSF13 Antibody

Target: TNFSF13 (Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13))

Binding Specificity: AA 196-210

Reactivity: Human, Drosophila melanogaster

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFSF13 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Reacts with the extracellular domain 2 of human APRIL. Cross-reacts with drosophila protein.

Purification: Purified

Immunogen: Peptide corresponding to aa 196-210 of human APRIL

Isotype: IgG

Application Details

Application Notes: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
WB(2 - 4 μg/mL) IHC(10 μg/mL)

Positive control: HL60 or Jurkat cell

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Target Details for TNFSF13

Target: TNFSF13 (Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13))

Alternative Name: APRIL (TNFSF13 Products)

Synonyms: APRIL antibody, CD256 antibody, TALL-2 antibody, TALL2 antibody, TRDL-1 antibody, ZTNF2 antibody, 2310026N09Rik antibody, April antibody, Tall2 antibody, Trdl1 antibody, SLAN antibody, ANP32B antibody, april antibody, tnf13 antibody, TNLG7B antibody, TNF superfamily member 13 antibody, tumor necrosis factor (ligand) superfamily, member 13 antibody, acidic leucine-rich nuclear phosphoprotein 32 family member B antibody, TNFSF13 antibody, Tnfsf13 antibody, LOC494442 antibody, tnfsf13 antibody

Background: This antibody recognizes human APRIL (A Proliferation-Inducing Ligand), a novel member of the TNF family. Two receptors for APRIL, TACI and BCMA were recently identified. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-κB, and induces cell death. APRIL is associated with autoimmune diseases and cancer.

Tumor necrosis factor ligand superfamily member 13 A proliferation-inducing ligand, APRIL TNF- and APOL-related leukocyte expressed ligand 2, TALL-2 TNF-related death ligand 1, TRDL-1 CD_antigen: CD256 Gene name: TNFSF13, APRIL, TALL2, ZTNF2, UNQ383/PRO715

Gene ID: 8741

UniProt: O75888

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response