ARC (AA 191-208) antibody

Catalog No. ABIN1731925

Product Details

Target: ARC

Binding Specificity: AA 191-208

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Reacts with human ARC.

Purification: Purified

Immunogen: Peptide corresponding to aa 191-208 of human ARC.

Isotype: IgG

Application Details

Application Notes: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
IHC (5 μg/mL) WB(1 - 10 μg/mL)

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Dilute in PBS or medium that is identical to that used in the assay system.

Storage: -20 °C

Storage Comment: Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: ARC

Synonyms: activity regulated cytoskeleton associated protein antibody, Arc antibody

Background: A novel CARD domain-containing protein was recently identified and designated ARC (apoptosis repressor with CARD). ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1, and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue.

Nucleolar protein 3 Apoptosis repressor with CARD Muscle-enriched cytoplasmic protein, Myp Nucleolar protein of 30 kDa, Nop30 Gene name: NOL3, NOP

Gene ID: 8996

UniProt: O60936